Gata4 heart
WebMar 21, 2024 · GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart … WebApr 10, 2024 · Using a combination of in vivo and in vitro studies, we show that Rere and Gata4 interact genetically in the development of congenital heart defects, RERE positively regulates transcription from ...
Gata4 heart
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WebSep 24, 2014 · GATA4 chromatin occupancy changes markedly between fetal and adult heart, with a limited binding sites overlap. Cardiac stress restored GATA4 occupancy to a subset of fetal sites, but many... WebMar 15, 2016 · Altogether, our data demonstrate that GATA4 is required for neonatal heart regeneration through regulation of Fgf16, suggesting that paracrine factors could be of …
WebJan 4, 2011 · Abstract. We report that the dominant human missense mutations G303E and G296S in GATA4, a cardiac-specific transcription factor gene, cause atrioventricular septal defects and valve abnormalities by disrupting a signaling cascade involved in endocardial cushion development. These GATA4 missense mutations, but not a mutation causing … WebNational Center for Biotechnology Information
WebGata4 is a transcriptional activator of genes essential for cardiac function. Although important Gata4 transcriptional targets in the heart have been identified, such as Nppa, … WebJul 6, 2003 · Conversely, interaction of Gata4 and TBX5 was disrupted by specific human TBX5 missense mutations that cause similar cardiac septal defects. In a second family, we identified a frame-shift ...
WebSep 24, 2014 · GATA4 chromatin occupancy changes markedly between fetal and adult heart, with a limited binding sites overlap. Cardiac stress restored GATA4 occupancy to …
WebDec 4, 2024 · Cardiotoxicity, Heart Failure, Anthracycline, Breast Cancer, Chemotherapy. ... mediante el aumento de la expresión del GATA4. El carvedilol se asocia a menor deterioro de la FEVI en pacientes que reciben tratamiento con antraciclinas, aunque no mostró significación estadística. hossein jaberi ansariWebFeb 8, 2024 · Interestingly, GATA4, a critical cardiac factor for neonatal heart regeneration, demonstrates parallel expression profile with the CUGBP1 during the postnatal period . hossein jabbariWebDec 31, 2013 · The transcriptional code that programs cardiac hypertrophy involves the zinc finger-containing DNA binding factors GATA-4 and GATA-6, both of which are required to mount a hypertrophic response of the adult heart. Here we performed conditional gene deletion of Gata4 or Gata6 in the mouse heart in conjunction with reciprocal gene … hosseini_vWebHealth in Fawn Creek, Kansas. The health of a city has many different factors. It can refer to air quality, water quality, risk of getting respiratory disease or cancer. The people you live … hossein jadvarWebAug 15, 2004 · 1. Calcineurin as a signaling factor in the heart. The hypertrophic growth of the myocardium is initiated and maintained by a wide array of endocrine, paracrine, and autocrine growth factors in response to increased work load, injury, or intrinsic defects in contractile performance. hosseini the kite runnerWebSep 11, 2024 · The bone morphogenetic protein (Bmp) signaling pathway and the basic helix–loop–helix (bHLH) transcription factor Hand1 are known key regulators of cardiac development. In this study, we investigated the Bmp signaling regulation of Hand1 during cardiac outflow tract (OFT) development. In Bmp2 and Bmp4loss-of-function embryos … hosseini vitaWebMar 17, 2011 · GATA4, MEF2A, and GATA4–MEF2A chromatin co-occupancy increased the likelihood that genes were differentially regulated by GATA4 plus MEF2A knock down by 2.6, 3.3, and 4.6-fold, respectively (χ 2 test; P < 0.0001). These 50 genes were significantly enriched in GO terms related to heart development and function . These data suggest … hossein jafari