Glycogen accumulation and phase separation

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August undefined, 2024

WebOct 21, 2024 · Glycogen Accumulation and Phase Separation Drives Liver Tumor Initiation. Scientists reported that glycogen accumulation was a key initiating oncogenic event during liver malignant transformation, and found that glucose-6-phosphatase catalyzing the last step of glycogenolysis was frequently downregulated to augment … WebGlycogen and lysosomal storage diseases affect multiple organ systems including the liver, skeletal muscle, heart, and brain and lead to the accumulation of large cytoplasmic inclusions (65, 66). It is therefore possible that nuclear deformation from intracellular stresses may contribute to disease progression in these cases as well.

Glycogen accumulation and phase separation drives liver

WebJan 15, 2014 · recommendation: In the absence of any treatment-related changes within a study, the degrees of glycogen demonstrated in Figure 1, Figure 2, and Figure 3 are considered background (spontaneous) … WebExpression of the glg operon and glycogen accumulation were carbon source- and growth phase-dependent, and were repressed by glucose. The highest intracellular glycogen … harrington langer \\u0026 associates

Glycogen Accumulation and the Induction of Nitrogenase

WebSep 25, 2024 · Glycogen is a storage molecule made up of a long chain of glucose molecules linked together by glycosidic bonds. Glycogen formation exists to store excess sugar that the body is not currently ... Webmaximum, a second phase of glycogen accumulation was observed in the heterocyst-free culture . Glycogen and nitrogenase activity in Anabaena 3149 100 0.5 0 10 20 30 0 10 30 WebNov 2, 2024 · Glycogen accumulation is a key carcinogenic event in the malignant transformation of the liver [8]. ... which blocks Hippo signaling through glycogen phase … charcuterie burette bolbec

XMU Research Team Discovers Glycogen Accumulation and Phase Separation ...

Mechanisms by Which Metabolic - SAGE Journals

WebJan 3, 2024 · The accumulation of protein aggregates is often harmful and even lethal to cells and has been reported to be associated with several human diseases, such as neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and prion disease [7]. ... pyroptosis, and ferroptosis. Phase separation is an idea drawn from the … WebNov 30, 2024 · Liu, Q. et al. Glycogen accumulation and phase separation drives liver tumor initiation. Cell 184 , 5559–5576 (2024) Article CAS Google Scholar harrington lantern chandelier smallWebConsistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. Thus, we … harrington law danville indiana

"WebMay 29, 2024 · To maximize glycogen accumulation, we hypothesized that cells lacking key enzymes in the glycogen breakdown pathways would result in faster production and/or higher titers of glycogen. We considered three gene knockouts at two key nodes in glycogen metabolism: malQ, glgP , and agpA ( Figure 1B ). " - Glycogen accumulation and phase separation

Glycogen accumulation and phase separation

WebSep 5, 2024 · Furthermore, additional studies identified novel roles of nuclear glycogenolysis as a supply of acetyl-CoA for epigenetic modulation (Sun et al, 2024), storage of glycogen in brown adipose fat mediated by gut microbiota (Li et al, 2024), and glycogen accumulation in liver cancer aiding in liquid–liquid phase separation fueling … WebGlycogen accumulation and phase separation drives liver tumor initiation. Journal content Created on Oct 21, 2024 by Cell. ... in Disciplines. Published in. Cell, Cell Press (Reed Elsevier) Content. Accumulated glycogen undergoes liquid-liquid phase separation to suppress Hippo signaling and drive liver tumor initiation. Qingxu Liu, Jiaxin Li ...

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WebOct 1, 2024 · A recent report found that glycogen accumulation and phase separation block the activation of the Hippo signal and consequently activates YAP1, which … Webthat glycogen accumulation blocks Hippo signalling, activates YAP, and thereby promotes tumorigenesis. ... Glycogen phase separation and liver cancer ORIgINAL AR tICLE L, Q. a. G

WebPublications related to biomolecular condensates, phase separation, llps and more. Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during liver malignant transformation. We found that glucose-6-phosphatase (G6PC) … WebGlycogen accumulation and phase separation drives liver tumor initiation. Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during liver malignant transformation. We found that glucose-6-phosphatase (G6PC) catalyzing the last ...

WebJul 8, 2024 · Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. ... f Glycogen accumulation and phase separation lead to ... WebOct 28, 2024 · Glycogen accumulation induces glycogen-Mst1/2 aggregate foci in cells, related to Figure 3 (A and B) Immunofluorescent staining of Mst1 (red) and DAPI ...

WebOct 26, 2024 · Glycogen accumulation and phase separation drives liver tumor initiation through blocking Hippo signaling. A research paper based on the results titled “Glycogen accumulation and phase separation drives liver tumor initiation” was published on the Cell website on 21 October 2024. Co-first authors of the paper are PhD students including Liu ...

WebMay 13, 2024 · Glycogen is a polysaccharide that comprises α-1,4-linked glucose backbone and α-1,6-linked glucose polymers at the branching points. It is widely found in organisms ranging from bacteria to eukaryotes. The physiological role of glycogen is not confined to being an energy reservoir and carbon source but varies depending on organisms. … charcuterie breton toucyWebConsistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. Thus, we concluded that cancer-initiating cells adapt a glycogen storing mode, which blocks Hippo signaling through glycogen phase separation to augment tumor incidence. harrington lake condo association venice flWebGlycogen accumulation and phase separation drives liver tumor initiation Qingxu Liu, Jiaxin Li, Weiji Zhang, Chen Xiao, Shihao Zhang, Cheng Nian, Junhong Li, Dongxue Su, … charcuterie brunch boardWebOct 21, 2024 · Europe PMC is an archive of life sciences journal literature. harrington law associatesWebGlycogen accumulation and phase separation drives liver tumor initiation. Journal content Created on Oct 21, 2024 by Cell. ... in Disciplines. Published in. Cell, Cell Press (Reed … charcuterie by marieWebJan 12, 2024 · Concept: Glycogen undergoes liquid–liquid phase separation and aggregates with MST1/2, inhibiting the Hippo pathway. ... Zhang, and colleagues … charcuterie burlington njWebGlycogen is a glucose polysaccharide occurring in most mammalian and nonmammalian cells, in microorganisms, and even in some plants. It is an important and quickly mobilized source of stored glucose. In vertebrates it is stored mainly in the liver as a reserve of glucose for other tissues. In hepatocyte cells it is accumulated and mobilized ... charcuterie burlington