WebFeb 27, 2006 · Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp 26 Glu) and less stable microtubules Malathi Hari; Frank Loganzo; Tami Annable; Xingzhi Tan; Sylvia Musto; Daniel B. Morilla; James H. Nettles; James P. Snyder; Lee M. Greenberger Author & Article Information Mol Cancer Ther (2006) 5 (2): 270–278. WebGo analysis of the protein changes identified upon paclitaxel resistance revealed that cell component enrichment related to mitochondria. Moreover, tubulin and mitochondrial proteins were the major cellular components with changes associated with paclitaxel treatment. This suggests that mitochondria may play a role in paclitaxel resistance.
Octreotide-Paclitaxel Conjugate Reverses Paclitaxel Resistance …
WebClass III beta-tubulin (TUBB3) reduces microtubule stability and confers resistance to microtubule-stabilizing taxanes, including paclitaxel and docetaxel. Pancreatic ductal adenocarcinomas show limited responsiveness to taxanes, but little is known of the underlying mechanisms. WebApr 6, 2024 · Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization Tubulin acetylation enhances lung cancer … family connection orange nj
Probes for Tubulin and Other Cytoskeletal Proteins—Section 11.2
WebThe proteins with ratio values of more than 1.2-fold or less than 0.83-fold (P<0.05) were considered as differentially expressed proteins (DEPs). In paclitaxel group compared with control, 499 DEPs were identified, 281 (56.3%) of which were up regulated and 218 (43.7%) of which were down-regulated. WebJun 13, 2024 · Paclitaxel (trade name Taxol) is a tricyclic diterpenoid compound naturally produced in the bark and needles of Taxus brevifolia.Its molecular formula is C 47 H 51 NO 14, and its chemical structure is shown in Fig. 1.Because of its unique anticancer mechanism, it is already one of the most successful and widely used natural anticancer … WebDec 1, 2024 · Four (4) possible mechanisms may account for paclitaxel resistance. (1) Increased expression of a drug pump, such as the ABC transporter, which causes the efflux of paclitaxel. (2) Altered expression of apoptotic genes, such as bcl2, that causes cells to defy death signals triggered by paclitaxel. family connection of warren county inc