Topotecan sicherheitsdatenblatt
WebTopotecan is a cytotoxic anti-cancer agent (semi-synthetic analogue of the alkaloid camptothecin). Topotecan is exerting its activity by the inhibition of the nuclear enzyme topoisomerase I that is involved in DNA replication. The inhibition is due to stabilisation of the intermediate covalent complex of enzyme and strand-cleaved DNA. WebTopotecan is a type of chemotherapy drug called a topoisomerase 1 inhibitor. It works by blocking a chemical called topoisomerase 1. This chemical helps to separate and repair the DNA in cells when they divide. Cancer cells need to make and repair DNA in order to grow and multiply. Blocking the action of this enzyme damages the DNA and so the ...
Topotecan sicherheitsdatenblatt
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WebCervical Cancer. Indicated for combination therapy with cisplatin for stage IV-B, recurrent or persistent cervical carcinoma which cannot be treated with surgery and/or radiation … WebJun 1, 2000 · The results of a new study demonstrate that one-third of patients with recurrent ovarian cancer who are categorized as platinum-sensitive respond to treatment with topotecan (Hycamtin). The multicenter trial, conducted by the Gynecologic Oncology Group (GOG) and published in the March issue of the Journal of Clinical Oncology, is the …
WebDilute Topotecan Injection in a minimum of 50 mL of 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP prior to administration. Infuse diluted Topotecan Injection over 30 minutes. Store diluted Topotecan Injection at 20°C and 25°C (68°F and 77°F) in ambient lighting conditions for no more than 24 hours. WebTopotecan (also called Hycamtin ®) is an anticancer medicine. It is available as a 0.25 mg capsule, a 1 mg capsule, and a liquid taken by mouth. It is also available as a light-yellow liquid given by vein (IV). Topotecan can pose a health hazard to caregivers. All caregivers should take safety precautions while giving this drug.
http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Topotecan%20monograph_1Feb2016.pdf WebTopotecan is a semisynthetic, water -soluble derivative of camptothecin, which is a cytotoxic alkaloid extracted from plants such as Camptotheca acuminata. Topotecan has the same mechanism of action as irinotecan. It inhibits the action of topoisomerase I, an enzyme that produces reversible single-strand breaks in DNA during DNA replication.
WebTopotecan is metabolized to an N-demethylated metabolite in vitro. The mean metabolite: parent AUC ratio was about 3% for total topotecan and topotecan lactone following intravenous administration. Excretion. The overall recovery of total topotecan and its N-desmethyl metabolite in urine and feces over 9 days averaged 73% ± 2% following an ...
WebTopotecan hydrochloride 119413-54-6 Not Listed Repr. Cat.2, R61; Mut. Cat.2, R46 3 Ingredient CAS Number EU EINECS/ELINCS List EU Classification % Mannitol 69-65-8 200-711-8 Not Listed * Tartaric acid 87-69-4 201-766-0 Not Listed * Water for injection 7732-18-5 231-791-2 Not Listed * phosphor minecraft modsWebTopotecan comes as a capsule to take by mouth. It may be taken with or without food. It is usually taken once a day for 5 days in a row every 21 days. Your doctor will decide how … phosphor mineralienWebTopotecan. Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. It is a synthetic, … phosphor mod forge 1.16.5WebPharmacodynamics. Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with … phosphor materialWebFor HYCAMTIN for injection in combination with cisplatin, reduce the dose to 0.6 mg/m. 2/day (and further to 0.45 mg/m. 2 if necessary) for: • febrile neutropenia (defined as neutrophil counts less than 1,000/mm3 with temperature of greater than or equal to 38.0°C (100.4°F) or administer G-CSF starting no sooner than 24 hours following the last dose how does a whitehead formWebJun 14, 2005 · Patients receive topotecan IV over 30 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After … how does a whole house attic fan workWebApr 28, 2024 · Topotecan Hospira is provided as a sterile concentrate containing 4 mg topotecan in 4 ml solution (1 mg/ml). Parenteral products should be visually inspected for particulate matter and discolouration prior to administration. Topotecan Hospira is a yellow/yellow green solution. If visible particles are observed, the product should not be ... how does a whistle work